LARGE LIBRARIES OF SINGLE-CHAIN TRIMER PEPTIDE-MHCS ENABLE ANTIGEN-SPECIFIC CD8+ T CELL DISCOVERY AND ANALYSIS

Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

Abstract The discovery and characterization of antigen-specific CD8+ T cell clonotypes typically involves EAR WAX RELIEF the labor-intensive synthesis and construction of peptide-MHC tetramers.We adapt single-chain trimer (SCT) technologies into a high throughput platform for pMHC library generation, showing that hundreds can be rapidly prepared ac

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Spectrum of Renal and Urinary Tract Diseases in Kashmiri Children

Introduction: Definite paucity of data pertaining to spectrum of renal and urinary tract diseases in our state and in various parts of India forms the basis of this study.Available data has emphasized more on specific clinical syndromes and chronic renal diseases rather than over all spectrums of renal and urinary tract diseases, that too in adult

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Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study

Abstract Background Low-grade glioma (LGG) is a relatively rare type of brain tumour.The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease.While epilepsy is well-described in patients with LGG, less is known about depression and anxiety.Methods We used nationwide registers to study the use (dispense) of

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Direct representation in Roman law with reference to modern law

The institute of direct representation is indispensable in contemporary law.The VALERICALM first modern civil codes acknowledged direct representation regulating power of attorney through a mandate contract.The second half of the 19th century saw a change in that perception.Starting with the German Civil Code, legal texts, including the Serbian Con

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